Rapid Detection of SARS-CoV-2 in Clinical and Environmental Samples via a Resonant Cavity SERS Platform within 20 min.

The coronavirus disease 2019 (COVID-19) epidemic has given a warning that it is important to explore the rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical specimens or environmental samples for public health strategies and future variants. The surface-enhanced Raman spectroscopy (SERS) technique was demonstrated to achieve this goal. However, the consistency of signals originating from the poor compatibility of virions with SERS hotspots remains a key scientific challenge for the practical applications of SERS. Herein, we develop a SERS platform for the ultrasensitive and rapid detection of SARS-CoV-2 antigen within 20 min by the combination of a highly consistent SERS substrate and a supervised deep learning algorithm. A V-shaped resonant cavity array (VRC) substrate was fabricated to trap SARS-CoV-2 virions in the periodic V cavity array and stimulate the integral SERS signal of the virus via a resonance coupling effect. Benefiting from the unique architecture of the VRC substrate, we were able to directly detect the SARS-CoV-2 virus with high sensitivity and high consistency. These excellent performances enabled us to identify five different kinds of SARS-CoV-2 variants and detect SARS-CoV-2 from clinical and environmental samples with high accuracies.

Generalized binary spiral zone plates with a single focus obtained by feedforward neural network.

Traditional spiral zone plates (SZPs) have been widely used to generate optical vortices, but this structure suffers from multiple focuses. To eliminate high-order foci, the current method is to design a binary structure that has a sinusoidal transmittance function along the radial direction. With the rapid development of artificial neural networks, they can provide alternative methods to design novel SZPs with a single focus. In this paper, we first propose the concept of generalized binary spiral zone plates (GBSZPs), and train a feedforward neural network (FNN) to obtain the mapping relationship between the relative intensity of each focus and the structural parameters of GBSZPs. Then the structural parameters of GBSZPs with a single focus were predicted by the trained FNN. It is found by simulations and experiments that the intensities of high-order foci can be as low as 0.2% of the required first order. By analyzing the radial transmittance function, it is found that this structure has a different distribution function from the previous radial sinusoidal function, which reveals that the imperfect radial sinusoidal form also can guide the design of binary zone plates to eliminate high-order foci diffraction. These findings are expected to direct new avenue towards improving the performance of optical image processing and quantum computation.

Design of an off-axis axiparabola with inclined wavefront correction to obtain a straight focal line.

The axiparabola is a novel reflective element proposed in recent years, which can generate a long focal line with high peak intensity, and has important applications in laser plasma accelerators. The off-axis design of an axiparabola has the advantage of separating the focus from incident rays. However, an off-axis axiparabola designed by the current method always produces a curved focal line. In this paper, we propose a new method to design its surface by combining geometric optics design and diffraction optics correction, which can effectively convert a curved focal line into a straight foal line. We reveal that the geometric optics design inevitably introduces an inclined wavefront, which leads to the bending of the focal line. To compensate for the tilt wavefront, we use an annealing algorithm to further correct the surface through diffraction integral operation. We also carry out numerical simulation verification based on scalar diffraction theory, which proves that the surface of this off-axis mirror designed by this method can always obtain a straight focal line. This new method has wide applicability in an axiparabola with any off-axis angle.

Target Density Effects on Charge Transfer of Laser-Accelerated Carbon Ions in Dense Plasma.

We report on charge state measurements of laser-accelerated carbon ions in the energy range of several MeV penetrating a dense partially ionized plasma. The plasma was generated by irradiation of a foam target with laser-induced hohlraum radiation in the soft x-ray regime. We use the tricellulose acetate (C_{9}H_{16}O_{8}) foam of 2 mg/cm^{3} density and 1 mm interaction length as target material. This kind of plasma is advantageous for high-precision measurements, due to good uniformity and long lifetime compared to the ion pulse length and the interaction duration. We diagnose the plasma parameters to be T_{e}=17 eV and n_{e}=4×10^{20} cm^{-3}. We observe the average charge states passing through the plasma to be higher than those predicted by the commonly used semiempirical formula. Through solving the rate equations, we attribute the enhancement to the target density effects, which will increase the ionization rates on one hand and reduce the electron capture rates on the other hand. The underlying physics is actually the balancing of the lifetime of excited states versus the collisional frequency. In previous measurement with partially ionized plasma from gas discharge and z pinch to laser direct irradiation, no target density effects were ever demonstrated. For the first time, we are able to experimentally prove that target density effects start to play a significant role in plasma near the critical density of Nd-glass laser radiation. The finding is important for heavy ion beam driven high-energy-density physics and fast ignitions. The method provides a new approach to precisely address the beam-plasma interaction issues with high-intensity short-pulse lasers in dense plasma regimes.

Accelerating superluminal laser focus generated by a long-focal-depth mirror with high numerical aperture.

The long-focal-depth mirror is a novel reflective element proposed in recent years. Due to the advantages of negligible dependence on wavelength and high damage threshold, it is suitable to focus ultra-short laser pulses with broadband spectra and high intensity with a focal depth of centimeter scale. To the best of our knowledge, the focusing properties of this mirror has been only studied under low numerical aperture (NA). In this paper, we extend it to the case of high NA and it is proved that an accelerating superluminal laser focus can be always generated by this extension, in which the degree of acceleration increases with the increase of NA. And the velocity of laser focus increases approximately linearly from c to 1.6c for NA = 0.707. Due to its properties of tight focusing, the Richards-Wolf integrals have been used to study the intensity distribution of each polarization component for different kinds of incident light. And these are linearly polarized light, radially polarized light, azimuthally polarized light, linearly polarized light with spiral phase, and linearly polarized light with ultrashort pulses. From comparisons of numerical results, the intensity distributions are obviously different for different kind of incident light, and accelerating superluminal laser focus with special structure (such as the hollow conical beam) can be produced under appropriate condition. We believe this study can expand the fields of application for the long-focal-depth mirror.

Selective generation of narrow-band harmonics by a relativistic laser pulse interaction with a detuned plasma grating.

The spectral characteristics of high-order harmonics generated by the interaction of a linearly polarized relativistic laser pulse with a plasma grating target are investigated. Through particle-in-cell simulations and an analytical model, it is shown that a plasma grating target with periodic structure can select special harmonics with integer multiples of the grating frequency, and that low-order harmonics with frequencies being integer times of the laser frequency are generated nearly parallel to the target surface from a Fresnel zone plate target with an aperiodic structure. Spectral control of the harmonics can be achieved by introducing a correction factor ß to the radius formula of the Fresnel zone plate, which can create a slightly detuned plasma grating, and then only the narrow-band harmonics can be selected nearly parallel to the target surface. The center order of the narrow-band harmonics can be tuned by adjusting the correction factor ß, while the bandwidth of the harmonics can be selected by adjusting the other parameter λ_{f} of the detuned plasma grating.

Observation of a high degree of stopping for laser-accelerated intense proton beams in dense ionized matter.

Intense particle beams generated from the interaction of ultrahigh intensity lasers with sample foils provide options in radiography, high-yield neutron sources, high-energy-density-matter generation, and ion fast ignition. An accurate understanding of beam transportation behavior in dense matter is crucial for all these applications. Here we report the experimental evidence on one order of magnitude enhancement of intense laser-accelerated proton beam stopping in dense ionized matter, in comparison with the current-widely used models describing individual ion stopping in matter. Supported by particle-in-cell (PIC) simulations, we attribute the enhancement to the strong decelerating electric field approaching 1 GV/m that can be created by the beam-driven return current. This collective effect plays the dominant role in the stopping of laser-accelerated intense proton beams in dense ionized matter. This finding is essential for the optimum design of ion driven fast ignition and inertial confinement fusion.

Binary sinusoidal single-order multilayer gratings for tender x-ray region.

We propose and theoretically analyze a single-order diffractive optical element, termed binary sinusoidal multilayer grating (BSMG), to effectively suppress high-order diffractions while retaining high diffraction efficiency in the first order. The key idea is to integrate sinusoidal-shaped microstructures with high-reflectivity multilayer coatings. The dependence of the high-order diffraction property on the microstructure shape and multilayer coatings is investigated. Theoretical calculation reveals that the second-, third-, fourth-, and fifth-order diffraction efficiencies are as low as 0.01%. Strikingly, we show that first-order relative diffraction efficiency (the ratio between the intensity of the first diffraction order versus that of the reflected light) as high as 97.7% can be achieved. Thus, the proposed BSMG should be highly advantageous in future development and application of tender x-ray spectroscopy.

Fractal spiral zone plate with high-order harmonics suppression.

We extend the concept of fractal spiral zone plates and define a new family of Cantor sequence spiral zone plates (CSSZPs) by removing the interference of high-order harmonics. In this typical design, apart from combining the spiral zone plates and Cantor fractal structure together, the desired physical properties have been realized by using a two-parameter modified sinusoidal apodization window along the azimuthal direction to eliminate the high-order harmonics. Numerical simulation reveals that the intensity of high diffraction orders of the CSSZPs can be effectively suppressed by at least 3 orders of magnitude, while the shapes of the sequences of focused optical vortices surrounding the first primary focal length are maintained, similar to those of the fractal spiral zone plates. The demonstration experiment, based on a spatial light modulator, has been also carried out to confirm the desired characteristics. This new kind of diffractive elements may offer potential alternatives for 3D optical tweezers, optical imaging, and lithography.

Suppression of higher diffraction orders in the extreme ultraviolet range by a reflective quasi-random square nano-pillar array.

Higher diffraction orders of a grating introduce so-called harmonics contamination that leads to ambiguity in the spectral data. They are also present in "monochromatic" output beams processed by grating monochromators at synchrotron radiation facilities, making calibration results of optical elements and detectors imprecise. The paper describes a new design of a reflective quasi-random square nano-pillar array grating to reduce the amount of data of the grating relief pattern that is 10 cm in size and suppresses higher diffraction orders in the extreme ultraviolet range. In addition, a laboratory-scale grating monochromator equipped with the grating has been developed to test its spectroscopy characteristics at grazing incidence. The results illustrate that it can suppress higher diffraction orders and maintain the spectral resolving power as an ordinary grating at grazing incidence. The grating has great potential in harmonics suppression in the field of synchrotron radiation, spectral diagnostics of plasma, and astrophysics.

Characterization of the focusing performance of axial line-focused spiral zone plates.

Axial line-focused spiral zone plates were developed for operation at optical wavelengths. The design, fabrication, and diffraction properties of the proposed element are presented. Numerical results showed that hollow beams could be generated, and that the element can be employed for a multi-wavelength operation. The hollow beam within the focal depth was demonstrated experimentally, using a charge-coupled device camera and sliding guide. The results were consistent with those obtained by the simulations. The proposed optical device exhibits significant potential for various applications including optical manipulation and lithography.

Quasi suppression of higher-order diffractions with inclined rectangular apertures gratings.

Advances in the fundamentals and applications of diffraction gratings have received much attention. However, conventional diffraction gratings often suffer from higher-order diffraction contamination. Here, we introduce a simple and compact single optical element, named inclined rectangular aperture gratings (IRAG), for quasi suppression of higher-order diffractions. We show, both in the visible light and soft x-ray regions, that IRAG can significantly suppress higher-order diffractions with moderate diffraction efficiency. Especially, as no support strut is needed to maintain the free-standing patterns, the IRAG is highly advantageous to the extreme-ultraviolet and soft x-ray regions. The diffraction efficiency of the IRAG and the influences of fabrication constraints are also discussed. The unique quasi-single order diffraction properties of IRAG may open the door to a wide range of photonic applications.

Realization of a flat-response photocathode for x-ray streak cameras.

We present a novel photocathode which can make x-ray streak cameras to be of a flat spectral response in the x-ray energy range of 0.1-5 keV. The photocathode consists of two layers of gold foils with optimized thickness ratio and structures. The photocathode was calibrated, and it is shown that a flat spectral response has been achieved.

Negative refraction in molybdenum disulfide.

Recently, negative refractions have been demonstrated in uniaxial crystals with no necessary of negative permittivity and permeability. However, the small anisotropy parameterγin the uniaxial crystals limits the negative refraction occurrence only in a small range of the incident light angle, retarding its practical applications. In this paper, we report negative refraction induced by a pronounced anisotropic behavior in the bulk MoS(2). Using the first-principles, the dielectric function and refractive index calculations confirm a uniaxial trait of MoS(2) with a calculated anisotropy parameterγlarger than 2.5 in the entire range of visible wavelength. The critical incident angle to trigger a negative refraction in the bulk MoS(2) is calculated up to 90°. The finite-difference time-domain simulations prove that the incident light with a density of 59.5% can be negatively refracted in a MoS(2) slab with a thickness of 0.1 µm. Our results open up a new pathway for MoS(2)-like materials to a novel field of optical integration.

Focusing single-order diffraction transmission grating with a focusing plane perpendicular to the grating surface.

By combining the single-order dispersion properties of quasi-sinusoidal single-order diffraction transmission gratings (QSTG) and the single-foci focusing properties of annulus-sector-shaped-element binary Gabor zone plate (ASZP), we propose a novel focusing single-order diffraction transmission grating (FSDTG). Different from the diffraction patterns of a normal transmission grating (TG), it has a focusing plane perpendicular to the grating surface. Numerical simulations are carried out to verify its diffraction patterns in the framework of Fresnel-Kirchhoff diffraction. Higher-order diffraction components of higher harmonics can be effectively suppressed by the FSDTG we designed. And we find that the focal depth and resolving power are only determined by the structure parameters of our FSDTG by theoretical estimations.

Single-order diffraction grating designed by trapezoidal transmission function.

Diffraction grating is a widely used dispersion element in spectral analysis from the infrared to the x-ray region. Traditionally, it has a square-wave transmission function, suffering from high-order diffraction contamination. Single-order diffraction can be achieved by sinusoidal amplitude transmission grating, but the fabrication is difficult. Here, we propose a novel idea to design a grating based on trapezoidal transmission function, which makes traditional grating a special case. Grating designed by this idea can not only suppress higher order diffraction by several orders of magnitude as sinusoidal amplitude grating does but also greatly reduce the fabrication difficulty to the level of processing for traditional grating. It offers a new opportunity for fabrication of grating with single-order diffraction and measurement of spectrum without contamination of high-order harmonic components. This idea can easily extend to varied-line-space grating, concave grating with single-order diffraction, or zone plates with single foci and will bring great changes in the field of grating applications.